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    Toxicology of Degradation Products of Plastics

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    A successful implant must meet two important criteria: (1) the ability to function in a living organism and (2) biocompatibility. If an implant has a tendency to degrade, both of these characteristics can be altered, leading to a failure of the implant and possible harm to the patient. This paper will deal with a brief discussion of the subject of toxicology, followed by selected examples of problems which have occurred in the use of a plastic for a biomedical application, and, finally. suggestions will be made as to in-vivo and in-vitro tests which may be appropriate for ascertaining whether a new plastic will degrade, releasing biologically active constituents.


    implant materials, toxicology, toxicological testing, biomaterials, cancer studies, biodegradation, plastics, polymers

    Author Information:

    Autian, J
    Director, Materials Science Toxicology Laboratories, University of Tennessee Center for the Health Sciences, Memphis, Tenn

    Committee/Subcommittee: F04.19

    DOI: 10.1520/STP35934S