SYMPOSIA PAPER Published: 01 October 1979
STP35934S

Toxicology of Degradation Products of Plastics

Source

A successful implant must meet two important criteria: (1) the ability to function in a living organism and (2) biocompatibility. If an implant has a tendency to degrade, both of these characteristics can be altered, leading to a failure of the implant and possible harm to the patient. This paper will deal with a brief discussion of the subject of toxicology, followed by selected examples of problems which have occurred in the use of a plastic for a biomedical application, and, finally. suggestions will be made as to in-vivo and in-vitro tests which may be appropriate for ascertaining whether a new plastic will degrade, releasing biologically active constituents.

Author Information

Autian, J
Materials Science Toxicology Laboratories, University of Tennessee Center for the Health Sciences, Memphis, Tenn
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Details
Developed by Committee: F04
Pages: 5–19
DOI: 10.1520/STP35934S
ISBN-EB: 978-0-8031-4751-5
ISBN-13: 978-0-8031-0313-9