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    A Radiorespirometric Study of the Effects of a Chemical Substance on Carbohydrate Metabolism in the Intact Fish

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    The effects of potassium pentachlorophenate (KPCP) on carbohydrate metabolism in the fish (Cichlasoma bimaculatum) were studied using radiorespirometry. Analysis of the patterns of radiolabeled carbon dioxide (14CO2) recovery from fish exposed to 0, 0.2, and 1.5 ppm of KPCP and metabolizing specifically labeled carbon-14 (14C)-glucose and acetate indicated that this species of fish uses the Embden-Meyerhoff-Parnas (EMP), pentose phosphate (PP), and glucuronic acid (GA) pathways in conjunction with the tricarboxylic acid (TCA) cycle for metabolizing carbohydrates. The KPCP stimulated the EMP pathway and the TCA cycle and presumably reduced the utilization of the PP and GA pathways.


    radiorespirometry, carbohydrate metabolism, pentachlorophenol, fish, glucose, acetate, aquatic toxicology, hazard assessment, gluconate, glucuronate

    Author Information:

    Liu, DHW
    Senior project scientist, Woodward-Clyde Consultants, San Francisco, Calif.

    Committee/Subcommittee: D19.05

    DOI: 10.1520/STP34174S