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The beneficial effect of seeding endothelial cells on synthetic vascular conduits has been well established by Herring, Graham, Schmidt, and others. This report discusses the biochemical production and interaction of the prostaglandins, prostacyclin (PGI2) and thromboxane (TXA2). A series of animal implantations was carried out with seeded and nonseeded grafts. Animals were medicated with cyclooxygenase inhibitors and TXA2 synthase inhibitors. Analysis was performed of PGI2 and TXA2 production on seeded and nonseeded grafts. Results of this analysis indicate: (1) seeded endothelial cells in Dacron® velour grafts can synthesize PGI2, (2) the levels of PGI2 from seeded endothelial cells are far less than the adjacent carotid artery, (3) the biochemistry of PGI2 production can be modulated by various antiplatelet agents, and (4) TXA2 synthase inhibitors improve thromboresistance of seeded grafts without significant effect on PGI2 production.
endothelial cell seeding, prostacyclin, thromboxane, vascular prostheses, cyclooxygenase inhibitors, thromboxane synthase inhibitors, enzymatic harvest of endothelial cells, small artery grafts
Director, Vascular Research Laboratory, Akron City Hospital, Akron, OH
Associate directoradjunct associate professor of biology, Research Laboratory, Akron City HospitalInstitute for Biomedical Engineering Research, The University of Akron, AkronAkron, OHOH
Research technician, Vascular Research Laboratory, Akron City Hospital, Akron, OH