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Bioprosthetic grafts are combinations of synthetic and natural materials intended to serve as high-integrity blood conduits when the ideal natural arterial substitute is not available. This article focuses on those combinations of tissue and synthetic materials, usually stabilized with some cross-linking reagent, that are meant to function from the instant of implantation as thromboresistant conduits inciting minimal reactions on their blood flow surfaces while also fostering integration with the surrounding host tissue. Several major problems associated with bioprosthetic grafts are discussed, as well as their advantages.
bioprosthetic grafts, synthetic materials, host tissue
Director, Health-care Instruments and Devices Institute (HIDI), State University of New York at Buffalo, Buffalo, NY