SYMPOSIA PAPER Published: 01 January 1985
STP32847S

Pulmonary Effects of Inhaled Sulfur Dioxide in Atopic Adolescent Subjects: A Review

Source

Atopic adolescent subjects with and without hypersensitive airways, as defined by responses to exercise challenge and methacholine challenge, have been studied during acute exposure to 1 ppm sulfur dioxide (SO2) and sodium chloride (NaCl) droplet aerosol. Changes in lung function following exposure were assessed by measuring total respiratory resistance, maximum flow at 50 and 75% of vital capacity, and forced expiratory volume in 1 s (FEV1). Atopic adolescent subjects with extrinsic asthma and exercise-induced bronchospasm were extremely susceptible to inhaled SO2 at the concentration used. As a group they showed a 23% decrease in FEV1 and a 67% increase in total respiratory resistance, and some had symptoms of wheezing and shortness of breath. On the other hand, atopic adolescent subjects with no signs of airway hypersensitivity were no more susceptible to inhaled SO2 than were a group of healthy adolescent subjects studied for comparison.

Author Information

Koenig, JQ
School of Public Health and Community Medicine, University of Washington, Seattle, WA
Pierson, WE
School of Public Health and Community Medicine, University of Washington, Seattle, WA
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Details
Developed by Committee: D22
Pages: 85–91
DOI: 10.1520/STP32847S
ISBN-EB: 978-0-8031-4937-3
ISBN-13: 978-0-8031-0406-8