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Practical and theoretical solutions to the quantitation of chemical accumulation by aquatic animals are evaluated. Laboratory studies presently rely on continuous exposure for extended periods of time to simulate field conditions. Application of the principles of pharmacokinetics permit laboratory results to be compared and indicate that mathematical models can be derived to predict contaminant accumulation under natural conditions adequately. Additional laboratory studies with large-sized and growing fish are identified as future research needs.
water analysis, toxicology, bioconcentration factor, bioaccumulation, pollutant chemicals, aquatic animals, hazards, residue dynamics, uptake, depuration, pharmacokinetic models
Senior scientist, Lilly Research Laboratories, Greenfield, Ind.