SYMPOSIA PAPER Published: 01 January 1983
STP30157S

Assessment of Biocompatibility of Orofacial Materials and Devices by Culturing with Human Excised Donor Tissues

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Three methods for assessing biocompatibility of materials used in orofacial constructs have been studied. These methods are (1) human excised donor (HED) orofacial tissues cultured in medium containing processed human serum, (2) an established cell line cultured in a serum free medium, and (3) an established human cell line cultured in a medium containing processed human serum. Of the three methods, the first was preferred since the cells used were removed recently from their total human physiology and may provide the most realistic evaluation of human-tissue response.

Author Information

Lontz, JF
Maxillofacial Prosthetics Center, Veterans Administration Medical Center, Wilmington, Del.
Nadijcka, MD
Maxillofacial Prosthetics Center, Veterans Administration Medical Center, Wilmington, Del.
Holmes, R
Maxillofacial Prosthetics Center, Veterans Administration Medical Center, Wilmington, Del.
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Details
Developed by Committee: F04
Pages: 77–87
DOI: 10.1520/STP30157S
ISBN-EB: 978-0-8031-4876-5
ISBN-13: 978-0-8031-0249-1