SYMPOSIA PAPER Published: 01 January 1986
STP29036S

Validation of collaborative testing guidelines

Source

This paper is an evaluation of the effectiveness of collaborative testing guidelines applied to two multi-laboratory method validation studies conducted for the U.S. Environmental Protection Agency (EPA). The guidelines were developed for EPA's Office of Toxic Substances and modeled after those of the Association of Official Analytical Chemists and The American Society for Testing and Materials. They were applied, to a greater or lesser extent, in the conduct of validation studies of the EPA's interim Ames test mutagenicity assay and Daphnia magna life-cycle toxicity assay. At the conclusion of the testing phase of the studies, each participant was requested to provide information related to key guideline elements. In addition, the organizers of each study indicated the degree to which they followed or did not follow the guidelines in administering their studies. Both participants and organizers were urged to provide recommendations for improving the way in which such studies are conducted in the future. The results are the basis for validation and appropriate revision of the collaborative testing guidelines. Results are presented and the implications of those results for future collaborative studies are discussed.

Author Information

Williams, LR
Quality Assurance Division, Las Vegas, NV
Meckley, DR
ICAIR Division, Life Systems Incorporated, Cleveland, OH
Schiefer, GE
ICAIR Division, Life Systems Incorporated, Cleveland, OH
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Details
Developed by Committee: E47
Pages: 335–348
DOI: 10.1520/STP29036S
ISBN-EB: 978-0-8031-4986-1
ISBN-13: 978-0-8031-0489-1