SYMPOSIA PAPER Published: 01 January 1986
STP29031S

Bioconcentration, Detoxification, and Excretion of Mutagenic River Pollutants in Fish Bile

Source

The continuous presence of unknown Salmonella mutagens in XAD-concentrates of Rhine river water has been shown previously. Using nitro-reductase deficient bacterial strains and silica fractionation, it was strongly indicated that the responsible compounds may consist of nitro substituted aromatics (with additional polar groups or heterocyclic structures) and aromatic amines. It was further shown that the same type of mutagens could be detected (104-fold increase) in the bile of rainbow trout exposed to Rhine river water. Considerating the accumulated mutagenic activity in natural occurring fish, this observation argues in favor of a true bioconcentration process of water-borne mutagens in fish bile. The clearance of mutagenic activity of bile after transferring the fish to clean water again is indicative for the importance of biliary excretion of xenobiotics and their metabolites.

Author Information

van Kreijl, CF
Laboratory of Mutagenesis and Carcinogenesis, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
de Zwart, D
Laboratory of Ecology, Water, and Drinking Water, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
Slooff, W
Laboratory of Ecology, Water, and Drinking Water, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands
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Details
Developed by Committee: E47
Pages: 268–276
DOI: 10.1520/STP29031S
ISBN-EB: 978-0-8031-4986-1
ISBN-13: 978-0-8031-0489-1