SYMPOSIA PAPER Published: 01 January 1983
STP28948S

Cartilage and Bone Ingrowth into Porous Titanium Implants

Source

Cultured lapine articular chondrocytes were transplanted onto porous Ti-6Al-4V alloy and placed into osteochondral defects of 26 rabbit medial femoral condyles. At four, eight, and twelve weeks, the surface of porous titanium with a cell culture implant was compared with the animal's control knee, which had not received the cultured chondrocytes. Histologic examination of the articular surface revealed chondrocytes with metachromatic ground substance in 35 percent of the experimental knees. In the remaining 65 percent, either thick fibrous tissue or fibrocartilage was evident. The control knees revealed dense fibrous tissue. Thus, cultured chondrocytes can be grown on a porous titanium surface in vivo. However, the histologic appearance is not that of normal articular chondrocytes.

Author Information

Nelson, DD
University of Pittsburgh, Pittsburgh, Pa.
Rubash, HE
University of Pittsburgh, Pittsburgh, Pa.
Mears, DC
University of Pittsburgh, Pittsburgh, Pa.
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Details
Developed by Committee: F04
Pages: 255–264
DOI: 10.1520/STP28948S
ISBN-EB: 978-0-8031-4862-8
ISBN-13: 978-0-8031-0241-5