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The Toxic Substances Control Act (PL 94-469) directs the U.S. Environmental Protection Agency (EPA) to produce standards for the development of adequate data regarding the effect of chemical substances and mixtures on health and the environment. The agency is developing test standards to satisfy this charge. This paper describes part of the process by which a test standard is developed, using the avian dietary median lethal concentration (LC50) toxicity test as an example. The history of avian dietary toxicity test methods is briefly described, along with the kinds of modifications in methods made by various users. The rationale for the selection of specific test conditions and procedures is discussed with respect to the use of the test results by a regulatory agency. Selection criteria for several controversial test parameters are presented as examples.
avian dietary toxicity testing, terrestrial toxicology, Toxic Substances Control Act, birds, wildlife, toxicology
Biologist, Health and Environmental Review Division, Office of Pesticides and Toxic Substances, U.S. Environmental Protection Agency, Washington, D.C.,