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Investigations were conducted to establish criteria for selecting animals used in coyote chemosterilant research. Conclusions based on results from this study indicate that pen-raised pregnant female coyotes are preferable to wild coyotes for evaluating chemicals for abortifacient properties. Dogs were more practical than coyotes for preliminary out-of-season testing of antispermatogenic agents. Wild or pen-raised coyotes were suitable for use when necrotizing agents were used.
Selected standard hematologic and blood chemistry determination techniques were applicable for the purpose of monitoring systemic side effects of chemosterilant compounds.
Efficacy determination methodology was reviewed for practicality and accuracy. Unilateral testicular ablation was more suitable than biopsy techniques for collection of testicular tissue for histological examination.
vertebrate pest control, coyote, chemosterilant, antifertility, anti-spermatogenic, abortion, hematologic, blood chemistry
Veterinary medical officer, U.S. Department of Agriculture, Agricultural Research Service, Dubois, Idaho