You are being redirected because this document is part of your ASTM Compass® subscription.
    This document is part of your ASTM Compass® subscription.


    Design Criteria for Safety in the Isolation and Purification of Antibiotics and Biologically Active Compounds

    Published: 0

      Format Pages Price  
    PDF (128K) 9 $25   ADD TO CART
    Complete Source PDF (2.3M) 155 $55   ADD TO CART

    Cite this document

    X Add email address send
      .RIS For RefWorks, EndNote, ProCite, Reference Manager, Zoteo, and many others.   .DOCX For Microsoft Word


    A summary is presented of safety-related design considerations and practices in the isolation and purification of antibiotics and other biologically active compounds from fermentation broths, as practiced by Merck & Co., Inc., in current production operations.

    Profiles of physical activity are established on process streams, isolated intermediates, and the final bulk active compound. Design criteria for worker protection are developed based on these profiles.


    bioprocessing, fermentation isolation, physiological profile

    Author Information:

    Paul, EL
    Senior scientist, Merck Sharp & Dohme Research Laboratories, Rahway, NJ

    Committee/Subcommittee: E48.01

    DOI: 10.1520/STP26069S