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The National Institutes of Health (NIH) first developed guidelines for the safe laboratory use of recombinant DNA in 1976. The NIH organized the Recombinant DNA Advisory Committee (RAC) to advise and guide work in this area. The RAC consists of biomedical researchers and members from the general public.
The NIH guidelines have been modified several times since 1976 as new data have become available. This flexibility has enabled the RAC to keep pace with the rapid developments occurring in research and development in this area. The scope, content, and methods of revision of the NIH guidelines are described. The scope and objectives of the RAC are also described. Available data suggest that the RAC has made significant contributions to the field and has created a high degree of confidence among scientists and the public.
bioprocessing, Recombinant DNA Advisory Committee (RAC), recombinant DNA, NIH Recombinant DNA Advisory Committee, molecular biology, genetic engineering
Presidentchair, Coriell Institute for Medical ResearchNIH Recombinant DNA Advisory Committee, National Institutes of Health, CamdenWashington, NJD.C.