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This review examines the relationship between vitamin C, vitamin E, selenium, copper, zinc, and other dietary antioxidants and the so-called antioxidant defense systems of the lung. The effects of severe caloric and protein malnutrition and vitamin B-6 deficiency on lung development will also be reviewed. The animal models of oxidant-induced injury discussed include those for paraquat, ozone, nitrogen dioxide, and oxygen toxicity, as well as selected experiments with in vitro systems. Susceptible human populations at risk for oxidant-induced lung damage by virtue of nutritional deficiencies are identified and discussed.
nutrition, oxidants, vitamin E, vitamin C, selenium, copper, zinc, lung, paraquat
Professor of internal medicine, School of Medicine and Toxic Substances Program, LEHR Facility, University of California, Davis, CA