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Understanding and describing variations in responsiveness to inhaled toxins among individuals is a challenging intellectual task as well as as essential step in the regulatory process. Both altered exposure-dose relationships and dose-response relationships can contribute to the process. Better assessment of the degree of susceptibility and the number and geographical distribution of more responsive individuals is urgently needed. Only then can we design and implement strategies to protect all individuals.
air pollution, susceptibility, respiratory tract, variability
Professor of Environmental Physiology and Director of Respiratory Biology Program, Harvard School of Public Health, Boston, MA