SYMPOSIA PAPER Published: 01 January 1991
STP17620S

Statistical Design and Analysis of Assays for Monitoring Waterborne Viruses

Source

An assumption often made in assaying for plaqueforming viruses is that the formation of plaques among several cell culture bottles will follow a Poisson distribution. Examining the results of several virus assays using Fisher's index of dispersion, the assumption of a Poisson distribution was found to be warranted in most cases, but not always. The distribution of plaque counts will affect the statistical evaluation of such data; confidence limits for virus titer based on Poisson statistics will be appropriate in many instances. For purposes of sample design, an approach based on the Poisson assumption is recommended.

Author Information

Wymer, LJ
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Details
Developed by Committee: D19
Pages: 509–523
DOI: 10.1520/STP17620S
ISBN-EB: 978-0-8031-5163-5
ISBN-13: 978-0-8031-1407-4