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Although devices made of titanium and its alloy with 6% aluminum and 4% vanadium have been remarkably successful primarily in orthopaedic and dental applications, clinical reports have implicated the biological response to released metal from this class of metals as a cause of failure. It is our hypothesis that in the absence of wear, the amount of titanium released is small and will preferentially accumulate in local tissues. The data from this implantation study support the hypothesis. Although there is local accumulation of titanium released from an implant, in the absence of mechanically induced or assisted release, there is limited systemic transport and storage.
corrosion, metal ions, titanium, biocompatibility, orthopaedic implant
Former research fellow, University of Pennsylvania, Philadelphia, PA
Professor, University of Pennsylvania, Philadelphia, PA
Chair, University of Alabama, Birmingham, AL