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Aseptic loosening is the most common cause of failure of joint arthroplasties. Although the exact pathogenesis of the loosening process is not completely understood, particles of polymethyl methacrylate and polyethylene appear to play a crucial role. This paper summarizes past and current clinical and experimental research on the biology of aseptic loosening of joint arthroplasties and discusses the important role of particulate polymeric debris.
particulates, implants, biomaterials, polymethyl methacrylate, polyethylene, particles, prosthetic loosening, arthroplasty
Assistant professor of surgery, Stanford University Medical Center, Stanford, CA
Associate professor and director, Bone and Joint Research Laboratory, Department of Pathology, The Princess Margaret and Wellesley Hospitals, University of Toronto, Toronto,