SYMPOSIA PAPER Published: 01 January 1999
STP14275S

Serum Protein Carriers of Chromium in Patients with Cobalt-Base Alloy Total Joint Replacement Components

Source

The distribution of chromium (Cr) in fractionated serum was studied from peripheral blood of patients with and without Cr-containing Cobalt-base alloy total joint replacements: 1)10 patients with cobalt-chromium-base alloy prostheses; and 2) 10 age-matched controls without implants. Two molecular weight ranges were found to primarily bind Cr (at ≈70 kD and ≈140–180 kD) in patients with Cobalt-base alloy total joint replacements. This pattern of concentration-dependent metal-protein binding within molecular weight ranges that include immunoglobulins warrants further investigation.

Author Information

Hallab, NJ
Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL
Jacobs, JJ
Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL
Skipor, A
Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL
Black, J
IMN Biomaterials, King of Prussia, PA
Mikecz, K
Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL
Galante, JO
Rush-Presbyterian-St.-Luke's Medical Center, Chicago, IL
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Details
Developed by Committee: F04
Pages: 210–219
DOI: 10.1520/STP14275S
ISBN-EB: 978-0-8031-5409-4
ISBN-13: 978-0-8031-2608-4