Journal Published Online: 16 March 2021
Volume 49, Issue 6

Evaluation of Antimicrobial, Antioxidant, and Cytotoxicity Activities of CuO Nanopellets Synthesized by Surfactant-Free Hydrothermal Method

CODEN: JTEVAB

Abstract

Copper oxide nanopellets (CONPs) were produced by hydrothermal strategy. The particles were characterized by distinctive techniques. The synthesized particles were found to have pellet morphology with nonuniform thickness and varying sizes extending between 200 and 550 nm. Studies revealed their microbial nature against both Gram-positive and Gram-negative microscopic organisms, specifically Staphylococcus aureus, Bacillus subtilis, Pseudomonas fluorescens, and Escherichia coli and a plant parasitic pathogen Fusarium oxysporum. Studies demonstrated the antioxidant ability of CONPs at higher concentrations. In this paper, cytotoxicity was measured by blood hemolysis. Anticancer activity of CONPs tested against PC-3, HCT116, A549 and MDA-MB-231 cell lines after 24 hours exhibited IC50 values of 72.27, 144.2, 173.9, and 13.07 μg/mL, respectively. Although these phenomena have been determined in other reports, this report is indeed of significance for CONPs within the particle length of 200–550 nm.

Author Information

Sathyananda, H. M.
Centre for Research and Evaluation, Bharathiar University, Coimbatore, Tamilnadu, India Department of Chemistry, Sir M. Visvesvaraya Institute of Technology, Bengaluru, Karnataka, India Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India
Prashanth, P. A.
Centre for Research and Evaluation, Bharathiar University, Coimbatore, Tamilnadu, India Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India Department of Chemistry, PES College of Engineering, Mandya, Karnataka, India
Prashanth, G. K.
Department of Chemistry, Sir M. Visvesvaraya Institute of Technology, Bengaluru, Karnataka, India Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India
Nagabhushana, B. M.
Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India Department of Chemistry, M. S. Ramaiah Institute of Technology, Bengaluru, Karnataka, India
Krishnaiah, G. M.
Department of Chemistry, Sir M. Visvesvaraya Institute of Technology, Bengaluru, Karnataka, India Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India
Nagendra, H. G.
Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India Department of Bio-Technology, Sir M. Visvesvaraya Institute of Technology, Bengaluru, Karnataka, India
Dileep, M. S.
Visvesvaraya Technological University, Jnana Sangama, Belagavi, Karnataka, India Department of Physics, Sir M. Visvesvaraya Institute of Technology, Bengaluru, Karnataka, India
Ananda, S.
Department of Chemistry, University of Mysore, Mysuru, Karnataka, India
Boselin Prabhu, S. R.
Department of Electronics and Communication Engineering, Surya Engineering College, Erode, Tamilnadu, India
Pages: 11
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Stock #: JTE20200538
ISSN: 0090-3973
DOI: 10.1520/JTE20200538