Journal Published Online: 01 March 2003
Volume 48, Issue 2

Identification and Quantitation of Gamma-Hydroxybutyrate (NaGHB) by Nuclear Magnetic Resonance Spectroscopy

CODEN: JFSCAS

Abstract

The most common means of identification of gamma-hydroxybutyrate (NaGHB) involves using Fourier transform infrared spectroscopy (FTIR) or gas chromatography-mass spectrometry (GC-MS) of a suitable derivative. However, these methods may be complicated by possible shifts in chemical equilibrium between gamma-hydroxybutyric acid (GHB), GHB salts and the precursor lactone, gamma-butyrolactone (GBL). This paper addresses the technique of proton and carbon nuclear magnetic resonance spectroscopy (1H and 13C NMR) for the direct and accurate identification of GHB and GBL. The application of 1H NMR for GHB quantitation is also discussed.

Author Information

Chew, SL
Drug Enforcement Administration, Western Laboratory, San Francisco, CA
Meyers, JA
Drug Enforcement Administration, North Central Laboratory, Chicago, IL
Pages: 7
Price: $25.00
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Stock #: JFS2002186
ISSN: 0022-1198
DOI: 10.1520/JFS2002186