Journal Published Online: 01 November 2002
Volume 47, Issue 6

Colchicine Poisoning Resulting from Accidental Ingestion of Meadow Saffron ( )

CODEN: JFSCAS

Abstract

A rare case of colchicine poisoning resulting from accidental ingestion of meadow saffron (Colchicum Autumnale) is reported. The plant can frequently be found in the woods of the Northern Hemisphere (1), also in Japan. A 48-year-old male was admitted to hospital complaining of vomiting, nausea and diarrhea following ingestion of the plant and died in four days. The most striking histological findings were metaphasic mitotic figures in the mucosa of the large intestine and the liver. Colchicine was detected in the bile with high-performance liquid chromatography/ sonicspray ionization mass spectrometry (HPLC/SSI-MS).

Author Information

Sannohe, S
Hirosaki University School of Medicine, Aomori, Japan
Makino, Y
Hirosaki University School of Medicine, Aomori, Japan
Kita, T
Hirosaki University School of Medicine, Aomori, Japan
Kuroda, N
Hirosaki University School of Medicine, Aomori, Japan
Shinozuka, T
School of Medicine, Keio University, Tokyo, Japan
Pages: 6
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Stock #: JFS15581J
ISSN: 0022-1198
DOI: 10.1520/JFS15581J