Journal Published Online: 01 July 2001
Volume 46, Issue 4

Length Variation in HV2 of the Human Mitochondrial DNA Control Region

CODEN: JFSCAS

Abstract

Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.

Author Information

Stewart, JEB
FBI Laboratory, Washington, D.C.
Fisher, CL
FBI Laboratory, Washington, D.C.
Aagaard, PJ
FBI Laboratory, Washington, D.C.
Wilson, MR
FBI Laboratory, Washington, D.C.
Isenberg, AR
FBI Laboratory, Washington, D.C.
Polanskey, D
FBI Laboratory, Washington, D.C.
Pokorak, E
FBI Laboratory, Washington, D.C.
DiZinno, JA
FBI Laboratory, Washington, D.C.
Budowle, B
FBI Laboratory, Washington, D.C.
Pages: 9
Price: $25.00
Related
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Details
Stock #: JFS15059J
ISSN: 0022-1198
DOI: 10.1520/JFS15059J