Journal Published Online: 01 September 1997
Volume 42, Issue 5

HLA-DQA1 and Polymarker Allele Frequencies in Two New York City Jewish Populations

CODEN: JFSCAS

Abstract

Allele and genotype frequencies were determined for the HLA-DQA1 and Amplitype® Polymarker loci (low density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8, and group-specific component (Gc)) in Hasidic and non-Hasidic Ashkenazi New York City Jewish subpopulations. For all loci tested, except HBGG, the 2 subpopulations meet the assumption of Hardy-Weinberg equilibrium. Comparison of various allele and genotype frequencies for the Hasidic and the non-Hasidic groups showed no significant differences. Comparison of the various allele frequencies in the two subpopulations to another Caucasian group revealed significant differences at the HLA-DQA1 and D7S8 loci in the Hasidic group. These frequency data can be used for comparison to other populations and for frequency estimates in DNA profiling.

Author Information

Medintz, I
Graduate School and University Center, City University of New York, NY
Levine, L
City College, City University of New York, NY
McCurdy, L
Mt. Sinai School of Medicine, City University of New York, NY
Chiriboga, L
Graduate School and University Center, City University of New York, NY
Kingston, C
John Jay College of Criminal Justice City University of New York, New York, NY
Desnick, RJ
Mt. Sinai School of Medicine, City University of New York, NY
Eng, CM
Mt. Sinai School of Medicine, City University of New York, NY
Kobilinsky, L
Graduate School and University Center, City University of New York, NY John Jay College of Criminal Justice City University of New York, New York, NY
Pages: 4
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Stock #: JFS14231J
ISSN: 0022-1198
DOI: 10.1520/JFS14231J