Journal Published Online: 01 July 1996
Volume 41, Issue 4

Purification and Determination Procedure of Coumarin Derivatives

CODEN: JFSCAS

Abstract

Anticoagulant coumarin derivatives, bromadiolone, brodifacoum, warfarin, and coumatetralyl were analyzed simultaneously with a modified analytical method. The method includes purification by Sep-Pak cartridge and HPLC analysis using isocratic elution with methanol: 0.8% Acetic acid (8:2). The recoveries of coumarin derivatives from biological samples ranged from 96 to 99%. The concentrations of coumarin derivatives in intoxicated rats' organ were also determined with this analytical procedure.

Author Information

Park, SW
The National Institute of Scientific Investigation, Seoul, Korea
Seo, BS
Catholic University Medical College, Seoul, Korea
Kim, EH
The National Institute of Scientific Investigation, Seoul, Korea
Kim, DH
The National Institute of Scientific Investigation, Seoul, Korea
Paeng, K-J
Yonsei University, Wonju, Korea
Pages: 4
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Stock #: JFS13979J
ISSN: 0022-1198
DOI: 10.1520/JFS13979J