Journal Published Online: 01 May 1994
Volume 39, Issue 3

A Fatality Involving Clothiapine and Clomipramine

CODEN: JFSCAS

Abstract

A fatality resulting from the suicidal ingestion of clothiapine, clomipramine and biperiden is reported. Clomipramine, its metabolite N-desmethylclomipramine and clothiapine were quantified in blood, liver, kidney and gastric contents by HPLC and GC. Biperiden was detected only in the gastric content. Significant differences of drug levels were found in postmortem blood obtained from brain and from heart. Concentrations of clomipramine and N-desmethylclomipramine ranged from 0.48 to 1.61 mg/L and 0.26 to 1.32 mg/L, respectively, and clothiapine from 0.50 to 2.15 mg/L. This phenomenon may reflect a postmortem drug redistribution.

Author Information

Romano, G
Istituto di Medicina Legale e delle Assicurazioni, Università di Catania, Catania, Italy
Bono, GD
Ospedale Civile E. Muscatello, Servizio di Anestesia e Rianimazione, Augusta, Italy
Pages: 6
Price: $25.00
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Stock #: JFS13668J
ISSN: 0022-1198
DOI: 10.1520/JFS13668J