Journal Published Online: 01 March 1994
Volume 39, Issue 2

3′,4′,5′-Trimethoxy-Substituted Analogs of Cocaine, -Cinnamoylcocaine and Tropacocaine: Characterization and Quantitation of New Alkaloids in Coca Leaf, Coca Paste and Refined Illicit Cocaine

CODEN: JFSCAS

Abstract

Four new alkaloids have been detected in South American coca leaf, coca paste and refined illicit cocaine. The compounds 3′,4′,5′-trimethoxycocaine (TMC), 3′,4′,5′-trimethoxytropacocaine (TMT), 3′,4′,5′-trimethoxy-cis-cinnamoylcocaine (cTMCC) and 3′,4′,5′-trimethoxy-trans-cinnamoylcocaine (tTMCC) were isolated from the coca leaf matrix and other alkaloids by toluene extraction followed by trap and ion-pair column chromatography. The identity of each alkaloid was verified via comparison of its mass spectrum with a synthesized standard. All four alkaloids were quantitated in leaf, paste and refined samples at levels of less than 0.1% relative to cocaine via capillary gas chromatography—flame ionization detection (cGC-FID).

Author Information

Casale, JF
Special Testing and Research Laboratory, U.S. Drug Enforcement Administration, McLean, VA
Moore, JM
Special Testing and Research Laboratory, U.S. Drug Enforcement Administration, McLean, VA
Pages: 11
Price: $25.00
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Stock #: JFS13617J
ISSN: 0022-1198
DOI: 10.1520/JFS13617J