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This is the author's thesis for the degree of doctor of medical knowledge at the Catholic University of Louvain. As such, it displays the virtues and deficiencies of that genre of scientific literature. It is the fifty-fifth in the series Acta Biomedica Lovaniensia, all of which are evidently doctoral theses from the University of Louvain.
Professor, George Washington University, Washington, D.C.
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