Journal Published Online: 01 September 1993
Volume 38, Issue 5

GC/MS Quantitation of Benzoylecgonine Following Liquid-Liquid Extraction of Urine

CODEN: JFSCAS

Abstract

An analytical procedure for the determination of benzoylecgonine in urine by GC/MS using a two step liquid-liquid extraction scheme has been developed. Benzoylecgonine is one of the principle metabolites of cocaine. The extraction uses a wash step prior to extraction and derivatization and requires 0.5 mL of urine. Benzoylecgonine is extracted in good % recovery at a basic pH by using 4 mL of dichloromethane. The method is accurate and sensitive and allows the quantitation of benzoylecgonine in urine at or below the National Institute on Drug Abuse confirmation cutoff level of 150 ng/mL.

Author Information

Gerlits, J
Utah State Crime Lab, Southern Utah University, Cedar City, UT
Pages: 5
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Stock #: JFS13525J
ISSN: 0022-1198
DOI: 10.1520/JFS13525J