Journal Published Online: 01 September 1991
Volume 36, Issue 5

Toxicological Analysis of a Fatal Baclofen (Lioresal) Ingestion

CODEN: JFSCAS

Abstract

A fatality following ingestion of the drug baclofen (Lioresal®) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.

Author Information

Fraser, AD
Dalhousie University, Halifax, Nova Scotia, Canada
MacNeil, W
Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia, Canada
Isner, AF
Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia, Canada
Pages: 7
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Stock #: JFS13182J
ISSN: 0022-1198
DOI: 10.1520/JFS13182J