Journal Published Online: 01 September 1991
Volume 36, Issue 5

Chloroquine Distribution in Postmortem Cases

CODEN: JFSCAS

Abstract

Chloroquine concentrations in blood and tissues were examined in overdose and non-overdose cases to determine appropriate ranges for interpretation. Twenty-nine literature overdose cases and 8 non-overdose literature cases were compared with this laboratory's findings. The results indicate significant postmortem redistribution of chloroquine. Combining this laboratory's results and the literature results indicates that using a liver concentration of 150 mg/kg as a cutoff between overdose and non-overdose concentrations properly identified 30 of the 34 published cases containing liver chloroquine and 19 of the 20 presented cases.

Author Information

Kuhlman, JJ
Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC
Mayes, RW
R.A.F. Institute of Pathology and Tropical Medicine, Aylesbury, Bucks, United Kingdom
Levine, B
Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC
Jones, R
Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC
Wagner, GN
Armed Forces Institute of Pathology, Washington, DC
Smith, ML
Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC
Pages: 8
Price: $25.00
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Stock #: JFS13178J
ISSN: 0022-1198
DOI: 10.1520/JFS13178J