Journal Published Online: 01 March 1991
Volume 36, Issue 2

The Identification and Quantitation of Pharmaceutical Preparations by Nuclear Magnetic Resonance Spectroscopy

CODEN: JFSCAS

Abstract

The identification and quantitation of pharmaceutical preparations is often the most time-consuming analysis performed in the forensic science laboratory. Because of their hygroscopic and polymorphic properties, matching infrared spectra are frequently difficult to obtain. Moreover, many of these compounds also fragment in such a manner that their mass spectra are difficult to interpret. Nuclear magnetic resonance offers an attractive alternative analysis since it avoids these problems and allows simultaneous identification and quantitation of dosage forms. Typical procedures are described for pharmaceutical forms of barbiturates, phenethylamines, quinazolones, benzodiazepines, and ethchlorvynol. This method has been successfully used and in most cases does not require a preliminary separation of the pharmaceutical preparation's components.

Author Information

Angelos, SA
U.S. Drug Enforcement Administration, North Central Laboratory, Chicago, IL
Janovsky, TJ
U.S. Drug Administration, Special Testing and Research Laboratory, McClean, VA
Raney, JK
U.S. Drug Enforcement Administration, North Central Laboratory, Chicago, IL
Pages: 8
Price: $25.00
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Stock #: JFS13038J
ISSN: 0022-1198
DOI: 10.1520/JFS13038J