Journal Published Online: 01 September 1990
Volume 35, Issue 5

Paternity Testing: Blood Group Systems and DNA Analysis by Variable Number of Tandem Repeat Markers

CODEN: JFSCAS

Abstract

Two recent paternity cases are reported. In the first case of paternity exclusion, deoxyribonucleic acid (DNA) restriction fragment length polymorphisms (RFLPs) on variable number of tandem repeat (VNTR) loci with multiple alleles were informative, as well as established systems of red blood antigens, red cell enzymes, serum proteins, and human leukocyte antigens. In the second case, in which both the alleged father and the first wife were deceased, the paternal genotype was determined by using genetic markers from the second wife and four children, which then were compared with the paternal alleles of the child in question, the plaintiff in this case. The high probability of paternity (0.999 998 7) made us conclude that the man probably was the actual father. The DNA analysis by VNTR probes appears to be quite valuable in the study of paternity cases.

Author Information

Akane, A
Shimane Medical University, Izumo, Japan
Matsubara, K
Shimane Medical University, Izumo, Japan
Shiono, H
Shimane Medical University, Izumo, Japan
Yuasa, I
Tottori University, School of Medicine, Yonago, Japan
Yokota, S-I
National Children's Medical Research Center, Taishido, Setagaya, Tokyo, Japan
Yamada, M
National Children's Medical Research Center, Taishido, Setagaya, Tokyo, Japan
Nakagome, Y
National Children's Medical Research Center, Taishido, Setagaya, Tokyo, Japan
Pages: 9
Price: $25.00
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Stock #: JFS12948J
ISSN: 0022-1198
DOI: 10.1520/JFS12948J