Journal Published Online: 01 July 1988
Volume 33, Issue 4

Tissue Distribution of Ethosuximide and Clobazam in a Seizure Related Fatality

CODEN: JFSCAS

Abstract

The case of a six-year-old male who died in a hospital while receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.

Author Information

Fraser, AD
Dalhousie University, Halifax, Nova Scotia, Canada
Isner, AF
Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia, Canada
Heifetz, SA
Department of Pathology, Izaak Walton Killam Hospital for Children, Halifax, Nova Scotia, Canada
Pages: 6
Price: $25.00
Related
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Details
Stock #: JFS12532J
ISSN: 0022-1198
DOI: 10.1520/JFS12532J