(Received 5 July 1986; accepted 26 August 1986)
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A fatality following ingestion of the tricyclic antidepressant carpipramine (Prazinil®) and ethyl alcohol is described. Carpipramine was quantitated by high performance liquid chromatography. The concentration of carpipramine was 2.0 mg/L in blood and 0.44 mg/L in urine. Ethyl alcohol was measured by headspace gas chromatography and found to be 105 mg/dL in blood and 55 mg/dL in the urine. Quantitative analysis of stomach contents was positive for carpipramine by thin-layer chromatography. To our knowledge, this is the first reported fatality involving carpipramine.
Head, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia
Chemist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia
Stock #: JFS12423J