Journal Published Online: 01 April 1986
Volume 31, Issue 2

A Fatality Involving Clomipramine

CODEN: JFSCAS

Abstract

A fatality following ingestion of the tricyclic antidepressant clomipramine (Anafranil®), alprazolam (Xanax®), and ethyl alcohol is described. Clomipramine and N-desmethylclomipramine were quantitated by high performance liquid chromatography and alprazolam by gas liquid chromatography. Concentrations of clomipramine and N-desmethylclomipramine were: in blood—0.84 and 1.4 mg/L; in urine—0.56 and 0.62 mg/L. Alprazolam concentration in blood was 0.069 mg/L. Ethyl alcohol was measured by headspace gas chromatography and found to be 375, 385, and 435 mg/dL in blood, urine, and vitreous humor, respectively. These findings are compared to previous reports of clomipramine related fatalities and alprazolam toxicity combined with ethyl alcohol.

Author Information

Fraser, AD
Dalhousie University, Halifax, Nova Scotia, Canada
Isner, AF
Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia, Canada
Moss, MA
Dalhousie University, Halifax, Nova Scotia, Canada
Pages: 6
Price: $25.00
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Stock #: JFS12312J
ISSN: 0022-1198
DOI: 10.1520/JFS12312J