Journal Published Online: 01 April 1986
Volume 31, Issue 2

Multicenter Evaluation of Ultrafiltration, Dialysis, and Thermal Coagulation as Sample Pretreatment Methods for the Colorimetric Determination of Paraquat in Blood and Tissues

CODEN: JFSCAS

Abstract

Three methods of sample pretreatment for the rapid colorimetric determination of paraquat were compared: ultrafiltration, dialysis, and thermal coagulation. Spiked autopsy blood and tissue samples were examined in parallel in Groningen and Krakow and some samples were interchanged. All three methods gave recoveries between 87 to 102%; accuracy at the 20-mg/L level was within 10% of the target value and coefficients of variation in the 10 to 60-mg/L range were between 3 to 15%. Determinations in blood and liver in a fatal case of Gramoxone® poisoning showed excellent agreement. Because of its reliability, speed, and simplicity, ultrafiltration is the method of choice.

Author Information

de Zeeuw, RA
State University, Groningen, AW, The Netherlands
Wijsbeek, J
State University, Groningen, AW, The Netherlands
Piet Franke, J
State University, Groningen, AW, The Netherlands
Bogusz, M
Institute of Forensic Medicine, Copernicus Medical Academy, Krakow, Poland
Kłys, M
Institute of Forensic Medicine, Copernicus Medical Academy, Krakow, Poland
Pages: 7
Price: $25.00
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Stock #: JFS12282J
ISSN: 0022-1198
DOI: 10.1520/JFS12282J