Journal Published Online: 01 October 1984
Volume 29, Issue 4

A Clandestine Approach to the Synthesis of Phenyl-2-Propanone from Phenylpropenes

CODEN: JFSCAS

Abstract

A number of published syntheses for the manufacture of controlled substances appear to be impractical for the average clandestine laboratory. A closer inspection of these syntheses may reveal modifications which greatly simplify their application. An excellent example of this is the preparation of phenyl-2-propanone (P-2-P) from allylbenzene. In the prototype published method, oxygen is introduced into the reaction vessel by using a tank of compressed oxygen with a balloon for a gas reservoir. In our modification, oxidation is accomplished with a 30% hydrogen peroxide solution. P-2-P has been prepared by both methods and a comparison made of the reaction mixtures at various times during their synthesis. Additionally, propenylbenzene, a by-product of these reactions, can be converted to P-2-P by modification of a second synthesis. Gas chromatography and nuclear magnetic resonance spectral data are presented for each method.

Author Information

Dal Cason, TA
Drug Enforcement Administration, North Central Laboratory, Chicago, IL
Angelos, SA
Drug Enforcement Administration, North Central Laboratory, Chicago, IL
Raney, JK
Drug Enforcement Administration, North Central Laboratory, Chicago, IL
Pages: 22
Price: $25.00
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Stock #: JFS11789J
ISSN: 0022-1198
DOI: 10.1520/JFS11789J