Journal Published Online: 01 October 1983
Volume 28, Issue 4

Determination of Chloroquine and Monodesethylchloroquine in Hair

CODEN: JFSCAS

Abstract

Using thin-layer and gas chromatography and mass spectrometry, chloroquine and its major metabolite (monodesethylchloroquine) were identified in hair samples of numerous patients who received this antimalarial drug for several months. In two patients the amounts of chloroquine were, respectively, 310 and 145 mg/kg hair and those of the monodesethylchloroquine 23 and 11 mg/kg. The respective proportions (93 and 7%) are the same in the two subjects. The chloroquine percentage was near those in the spleen or stomach wall after poisoning. Other metabolites in hair are being identified. Hair analysis may provide a good toxicologic and forensic science complement to the blood, urine, and tissues. It may be useful for the control of chloroquine therapy.

Author Information

Viala, A
Faculté de Pharmacie (Toxicologie), Marseille, France
Deturmeny, E
Faculté de Pharmacie (Toxicologie), Marseille, France
Aubert, C
Faculté de Pharmacie (Toxicologie), Marseille, France
Estadieu, M
Faculté de Pharmacie (Toxicologie), Marseille, France
Durand, A
Faculté de Pharmacie (Toxicologie), Marseille, France
Cano, JP
Faculté de Pharmacie (Toxicologie), Marseille, France
Delmont, J
Centre de Formation et de Recherche en Médecine et Santé tropicales, Hôpital Houphouët Boigny, Marseille, France
Pages: 7
Price: $25.00
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Stock #: JFS11600J
ISSN: 0022-1198
DOI: 10.1520/JFS11600J