Journal Published Online: 01 July 1983
Volume 28, Issue 3

Identification of Some Interferences in the Analysis of Clorazepate

CODEN: JFSCAS

Abstract

Clorazepate presents several problems in identification. In addition to rapid acid decarboxylation to N-desmethyldiazepam, a noncontrolled substance often confused with clorazepate, extracts of the pharmaceutical forms (Tranxene and Azenez capsules) contain substances that interfere with isolation of intact and unaltered clorazepate. These substances have been identified and have been found to be quite dependent on both capsule type and, especially, on capsule age. The cause of the conversion of dipotassium clorazepate to the monopotassium salt, following solution, has also been identified. An infrared analysis method, which removes all of the interferences, is presented.

Author Information

Suzuki, EM
Chemical Analysis Unit, Criminalistics Section, Crime Laboratory System, Washington State Patrol, Seattle, WA
Gresham, WR
Chemical Analysis Unit, Criminalistics Section, Crime Laboratory System, Washington State Patrol, Seattle, WA
Pages: 28
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Stock #: JFS11562J
ISSN: 0022-1198
DOI: 10.1520/JFS11562J