Journal Published Online: 01 January 1982
Volume 27, Issue 1

A Rapid Isolation Technique for Drugs from Tissues and Fluids: Use of the Du Pont Prep 1 System

CODEN: JFSCAS

Abstract

A microprocessor-controlled, automated extraction/concentration device, the Prep 1 (Du Pont Clinical Systems), was evaluated for application to the isolation of drug substances from postmortem fluids and tissue homogenates. Two classes of materials were investigated: barbiturates and the benzodiazepine, diazepam. With as little as 200 mg of tissue, barbiturate derivatives were successfully isolated and measured by gas chromatography using nitrogen-phosphorus detection with a coefficient of variation of 2 to 5%. Diazepam was measured in a similar fashion with a coefficient of variation of 4.4%. Preliminary investigation indicates that this system is applicable to a wide range of drug substances of toxicological interest.

Author Information

Balkon, J
St. Johns University, Jamaica, Queens, NY
Donnelly, B
Long Island Jewish-Hillside Medical Center, Glen Oaks, Queens, NY
Prendes, D
St. Johns University, Jamaica, Queens, NY
Pages: 9
Price: $25.00
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Stock #: JFS11447J
ISSN: 0022-1198
DOI: 10.1520/JFS11447J