Journal Published Online: 01 October 1981
Volume 26, Issue 4

Approaches to Drug Sample Differentiation. II: Nuclear Magnetic Resonance Spectrometric Determination of Methamphetamine Enantiomers

CODEN: JFSCAS

Abstract

Synthesized tris[d,d-dicampholylmethanato]europium(III), Eu(dcm)3, and three other commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance (NMR) spectra of the enantiomeric N-CH3 and C-CH3 protons in d- and l-methamphetamine. The chemical shift difference between the corresponding enantiomeric protons induced by these four shift reagents are compared and evaluated in their prospective use for enantiomeric identification and determination. It is concluded that while the chemical shift difference between the two enantiomerie C-CH3 protons induced by Eu(dcm)3 is most suitable for qualitative identification of these enantiomers, the NMR spectra of the N-CH3 protons are best resolved by Eu(dcm)3 and most suitable for quantitative determinations.

Author Information

Liu, JH
University of Illinois at Chicago Circle, Chicago, Ill.
Ramesh, S
University of Illinois at Chicago Circle, Chicago, Ill.
Tsay, JT
University of Illinois at Chicago Circle, Chicago, Ill.
Ku, WW
University of Illinois at Chicago Circle, Chicago, Ill.
Fitzgerald, MP
University of Illinois at Chicago Circle, Chicago, Ill.
Angelos, SA
North Central Regional Laboratory, Drug Enforcement Administration, Chicago, Ill.
Lins, CLK
University of Illinois at the Medical Center, Chicago, Ill.
Pages: 8
Price: $25.00
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Stock #: JFS11419J
ISSN: 0022-1198
DOI: 10.1520/JFS11419J