Journal Published Online: 01 January 1976
Volume 21, Issue 1

Studies on Fluorescamine: Part I—Applications of Fluorescamine in Forensic Toxicological Analysis

CODEN: JFSCAS

Abstract

Weigele and co-workers [1,2] reported the structure and synthesis of the reagent 4-phenylspiro [furan-2(3H), 1'-phthalan]-3,3'-dione (fluorescamine), which reacts with substances containing primary amino groups to yield highly fluorescent products. Recently, Undenfriend and co-workers [3–5] published a paper describing the use of fluorescamine in biochemical analysis. This reagent was of interest because of its possible use to improve the detection and differentiation of amphetamine and its relatives in biological samples and solid dosage forms. The main subject of this paper is to present data which clearly demonstrate the use of fluorescamine in forensic toxicological analysis of amphetamine and differentiation from methamphetamine. This reagent also has potential application for analysis of other drugs containing a primary amine group.

Author Information

Nowicki, HG
University of Maryland
Pages: 9
Price: $25.00
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Stock #: JFS10348J
ISSN: 0022-1198
DOI: 10.1520/JFS10348J