(Received 24 February 1975; accepted 7 April 1975)
Published Online: 1976
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The purpose of this study was to determine the effect of pretreatment with cannabidiol (CBD) or Δ-9-tetrahydrocannabinol (THC) on methaqualone (MQ)-induced sleeping times. The duration of sleep was determined as the interval between the loss of righting reflex and its return. Male albino mice were injected intraperitoneally (i.p.) with either CBD or THC (10, 20, or 30 mg/kg) or vehicle. Thirty minutes later, an hypnotic dose of MQ (75 mg/kg) was administered. Animals receiving CBD or THC alone would not sleep. The sleeping time for MQ alone was approximately 30 minutes. In the presence of CBD or THC, MQ sleeping times increased significantly. The effect of THC was significantly greater than that of CBD.
Graduate student, Indiana University School of Medicine, Indianapolis, Ind.
Chief toxicologist, Blodgett Memorial Hospital, Grand Rapids, Mich.
Professor of toxicology, Indiana University School of Medicine, Indianapolis, Ind.
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