Journal Published Online: 01 January 1972
Volume 17, Issue 1

Determination of Propoxyphene in Biological Materials by Ultraviolet Spectrophotometry and Gas Chromatography

CODEN: JFSCAS

Abstract

Propoxyphene has received widespread utilization as an analgesic agent. Originally thought to be nontoxic, the compound in recent years has been reported as a contributing agent in numerous intoxications of which several have been lethal [1]. The compound is a tertiary amino ester, α-d-4-dimethylamino-l-2-diphenyl-3-methyl-2-butanol propionate. Of the four possible stereoisomers only the α-d form has an analgesic effect [2–4]. Since propoxyphene absorbs ultraviolet radiation in the manner characteristic of benzenoid compounds, methods which utilize ultraviolet spectra of unconverted propoxyphene have little application to the analysis of this compound in biological systems [5].

Author Information

Wallace, JE
USAF School of Aerospace Medicine, Brooks Air Force Base, Texas
Ladd, SL
USAF School of Aerospace Medicine, Brooks Air Force Base, Texas
Blum, K
USAF School of Aerospace Medicine, Brooks Air Force Base, Texas
Pages: 10
Price: $25.00
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Stock #: JFS10125J
ISSN: 0022-1198
DOI: 10.1520/JFS10125J