Work Item
ASTM WK77765

Revision of E2526-08(2013) Standard Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials in Porcine Kidney Cells and Human Hepatocarcinoma Cells

Rationale

The proposed standard practice is derived from the standard method E2526 Standard Test Method for Evaluation of Cytotoxicity of Nanoparticulate Materials in Porcine Kidney Cells and Human Hepatocarcinoma Cells, first approved in 2008 and reapproved with no changes in 2013. The practice is intended to guide researchers in conducting the biological characterization of nanomaterials. The change in format from standard method to standard practice is needed due to the logistical challenges with conducting inter-laboratory studies aimed at defining the precision and bias of the method. Standard practices are more suitable for guiding researchers in the absence of nanoparticle standard reference materials and standardized human matrix (blood, bone marrow, kidney, and liver cells).

Details

Developed by Subcommittee: E56.03

Committee: E56

Staff Manager: Frank McConnell

Work Item Status

Date Initiated: 07-20-2021

Technical Contact: Marina Dobrovolskaia

Item: 003

Ballot: E56 (21-04)

Status: Will Reballot Item