1.Scope 1.1This test method covers the LCMSMS detection and quantitation of N-nitrosamines after direct injection. It has been validated for groundwater, surface water, wastewater influents, and wastewater effluents. This test method is not limited to these aqueous matrices; however, the applicability of this test method to other aqueous matrices must be demonstrated. 1.2This test method is applicable to nitrosamines that can be chromatographed and detected using a mass spectrometry procedure. Table 1 lists the compounds that have been validated for this test method. This test method is not limited to the compounds listed in Table 1; however, the applicability of the test method to other compounds must be demonstrated. 1.3Analyte concentrations from 0.05 g/L up to approximately 5 g/L may be determined without dilution of the sample. Analytes with insufficient sensitivity will not be detected, but they can be measured with acceptable accuracy and precision when present in sufficient amounts. In addition, newer instruments, or instruments of improved sensitivity may be used to lower detection limits. 1.4Analytes that are not separated chromatographically, but that have different mass spectra and noninterfering quantitation ions, can be identified and measured in the same calibration mixture or water sample. Analytes that have very similar product ions cannot be individually identified and measured in the same calibration mixture or water sample unless they have different retention times. 1.5It is the responsibility of the user to ensure the validity of this test method for untested matrices. 1.6This method is restricted to use by or under the supervision of analysts experienced in the use of a liquid chromatograph with tandem mass spectrometry. 1.7This method is performance based, however, each laboratory that uses this method must demonstrate the ability to generate results that meet or exceed the performance criteria of this method. 1.8The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only. 1.9This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
KeywordsEnvironmental; wastewater; water for reuse; EPA
5.1Nitrosamines are a class of nitrogen containing compounds with a known occurrence in wastewater. They may also be created in deionization and are a potential contaminant in water for reuse. The World Health Organization has issued a guideline for NDMA in drinking water at 0.1 g/L. NDMA may occur in chlorinated effluents and other wastewaters at concentrations of 0.02 g/L and higher. Other methods for nitrosamines employ solid phase extraction, which may not be applicable to wastewaters that contain particulate matter or a high organic load. This method analyses nitrosamines directly using LCMSMS. The method fits UN SDG #6 because it can be used to assess water quality, and #12 by reducing solvent usage (direct injection) and laboratory waste.
The title and scope are in draft form and are under development within this ASTM Committee.Back to Top
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