ASTM WK67498

    New Test Method for Determination of Cannabinoid Concentration in Cannabis Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

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    Developed by Subcommittee: D37.03 | Committee D37 | Contact Staff Manager


    1. Scope

    This test method details the analytical procedure for the analysis of cannabis to determine the identity and concentration of individual cannabinoids using liquid chromatography tandem mass spectrometry (LC-MS/MS). This procedure describes the analytical process beginning with sample preparation through cannabinoid quantitation. Cannabinoids that can be analyzed by this test method include delta-9-tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabinol (CBN) and other minor cannabinoids. This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.


    Cannabinoid; HPLC; LC-MS/MS; extraction; quantitation; laboratory


    This test method defines a procedure for determining the identification and concentration of cannabinoids in cannabis. This test method utilizes a highly selective analytical technique (LC-MS/MS) to minimize potential matrix interferences and may be used in support of programs that regulate the cultivation and distribution of cannabis.

    The title and scope are in draft form and are under development within this ASTM Committee.

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    Work Item Status

    Date Initiated:

    Technical Contact:
    Garnet McRae


    D37 (21-03)

    Negative Votes Need Resolution