ASTM WK65680

    New Test Methods for Printability of Bioinks and Biomaterial Inks

    (What is a Work Item?)

    Developed by Subcommittee: F04.42 | Committee F04 | Contact Staff Manager



    WK65680

    1. Scope

    1.1 This test method can be used to evaluate printability of bioinks and biomaterial inks used in automated biofabrication technology. Bioprinting is a way to synthesize living tissues using 3D printing techniques for applications within regenerative medicine, tissue engineering and drug testing. 1.2 These test methods are intended for use by manufacturers and researchers that produce bioinks and biomaterial inks to assess and compare printability of bioinks or biomaterial inks. Printability is one of several important parameters for precision manufacturing of 3D bioprinted parts. The two test methods described involve using an extrusion-based bioprinter to extrude multiple lines or to build up a wall as a means of assessing printability of bioinks and material inks. The test methods measure the ability of a bioink or material ink to (a) be extruded reproducibly through a nozzle during extrusion-based bioprinting, and (b) to maintain printed shape and dimensions during the addition of multiple layers above existing layers. 1.3 The effects of bioprinting on cell viability are not addressed in this standard. 1.4 The values are stated in SI units. No other units of measurement are included in this standard. 1.5 This standard does not purport to address all of the safety concerns, is any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.


    Keywords

    additive manufacturing, biofabrication, pluronics, gelatin-methacrylol

    Rationale

    The field of biofabrication is a subset of additive manufacturing that is expanding rapidly. Within the field of biofabrication, bioprinting refers to the synthesis of living tissues using 3D printing techniques for applications within regenerative medicine and drug testing. As an emerging field, there are many different manufacturers and academic researchers developing bioinks for delivering cells and biomaterial inks without cells used to support 3D printing of bioinks. As one of many envisioned standards in this area, the proposed standard would provide a test method to specify printability as a means to help establish reproducibility and quality control between material lots or manufacturers.

    The title and scope are in draft form and are under development within this ASTM Committee.

    Citing ASTM Standards
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    Work Item Status

    Date Initiated:
    11-02-2018

    Technical Contact:
    Liisa Kuhn

    Status:
    Draft Under Development